Thursday, July 22, 2010

Dangerously Damaging: What Happens to Women Who Live by the Scale

By: Jennifer Wider, MD
July 21, 2010

With so much attention focused on the obesity epidemic in the United States, eating disorders often receive less of the spotlight. But don’t let that fool you.

Eating Disorders, a set of conditions in which a person experiences severe disturbances in eating behavior, are widespread in our country. Roughly five to ten million American girls and women are currently battling eating disorders. Studies have shown that approximately 80 percent of American women are dissatisfied with their appearance at one time or another. According to statistics from the National Institute of Mental Health (NIMH) in Bethesda, Md., females are much more likely than males to develop an eating disorder. They most frequently appear during adolescence and young adulthood, but can show up at any time.

The two main forms of eating disorders are anorexia nervosa, or an extreme fear of gaining weight and relentless pursuit of thinness; and bulimia nervosa, a condition characterized by eating a significant amount of food (bingeing) and then ridding the body of the calories by throwing up or using laxatives or diuretics (purging). A third type, known as “eating disorders not otherwise specified (EDNOS)”, may incorporate several variations of anorexia and bulimia with other characteristics which can include binge-eating without purging, obsessive exercise and dietary rituals.

Eating disorders are often linked to other psychological conditions. “Depression, anxiety, and substance abuse are not uncommon among people with eating disorders,” explains Marlene B. Schwartz, Ph.D., clinical psychologist and Co-Director of the Yale Center for Eating and Weight Disorders in New Haven, Conn. Studies have shown that higher rates of depression among women and girls may be associated with a tendency to become more dissatisfied with physical appearance than their male counterparts.

Many medical conditions can result from eating disorders and they should not be taken lightly. For example, anorexia can slow the heart rate and clinically lower a person’s blood pressure, placing them at higher risk for heart problems. Nutritional deficiencies can lead to anemia, reduced muscle mass and light-headedness. Chronic starvation can lead to heart failure and brain damage.

Bulimia can cause a host of other medical conditions. For example, the acid in vomit can destroy the enamel of the teeth and inflame and erode the esophagus. Also, stomach and digestive issues from frequent purging are not uncommon in bulimic patients. Compulsive exercising can result in wear and tear injuries including shin splints, stress fractures, and damage to muscles and joints.

So what can you do? There may be several warning signs that a person could be developing an eating disorder, they include:

  • Food avoidance: pushing food around on a plate or avoiding meals with families and friends
  • Change in appetite
  • Preoccupation with food and calories
  • “Hiding behavior” - hiding the body under baggy clothes to disguise weight loss or disappearing after a meal to purge
  • An overuse of scales to weigh themselves

Concerned parents should pay close attention if their child is, “overly concerned with being fat, comparing themselves to their peers, partaking in excessive exercise, or over-using the internet to search for information on calories, diet, etc.,” according to Nikki Gorman, MD, a pediatrician at Village Pediatrics in Westport, Conn. These issues may be red flags or signal a good time to speak with a health professional.

The treatment for eating disorders depends on the extent of the problem. There are often a host of underlying issues that need to be addressed and the treatment will often have a multi-pronged approach which will focus on the person’s physical, emotional and nutritional needs.

Gorman summarizes, “If we can intervene early, it is usually possible to avoid costly treatment centers, and avoid some of the morbidity associated with an eating disorder.” This is good news for any parent and a step in the right direction in exposing the dangers of eating disorders.

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For more information on the Society for Women’s Health Research please contact Rachel Griffith at 202-496-5001 or Rachel@swhr.org.

The Society for Women’s Health Research (SWHR), a national non-profit organization based in Washington D.C., is widely recognized as the thought leader in women’s health research, particularly how sex differences impact health. SWHR’s mission is to improve the health of all women through advocacy, education and research. Visit SWHR’s website at swhr.org for more information.

Tuesday, July 20, 2010

SWHR Briefing Highlights Why the Bladder Matters

WASHINGTON, D.C. — The Society for Women’s Health Research (SWHR) hosted the Capitol Hill briefing, The Bladder Matters: What Women Need to Know on Thursday, July 15, which highlighted startling statistics and an insightful patient perspective. Featuring noted researchers, physicians, Hill staff, and a UI-afflicted patient, the aim of this widely attended briefing was to detail current research on urinary incontinence (UI) and present future outlooks.

Urological expert Janice Lee Arnold, M.D., a board-certified urologist with over 20 years of practice in the DC area, outlined the struggles that patients with UI and overactive bladder (OAB) face. OAB is defined as the urgency to urinate eight or more times per day and two or more times each night (nocturia) and is overwhelmingly found in women. Patients with OAB deal with many anxieties that worsen their symptoms: potential for embarrassment, limited travel options, distant or lost relationships, etc.

“Women suffering from OAB should seek treatment immediately because of the impact on overall quality of life, high risk for depression, and poorer quality of sleep,” said Dr. Arnold.

Robert Star, M.D., Director, Division of Kidney, Urologic, and Hematologic Diseases at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) shared new research on OAB and potential treatments. These novel treatment options include a newly funded urinary leakage detection system, a continuous drug delivery device to minimize the potential for accidents, and a Trojan Horse Drug Delivery system for bladder issues without the risk of systemic toxicity.

“Research into women’s OAB issues is a largely ignored topic and one that affects many women worldwide,” said Phyllis Greenberger, M.S.W., President and CEO of SWHR. “And this is why SWHR fiercely supports increased funding for innovative research into the pervasive diseases UI and OAB.”

Closing the panel with her poignant patient perspective, Ellen Exelbert shared her harrowing tale of OAB and how it disrupts her life on a daily basis. The victim of a defective cruise control mechanism, Exelbert suffered major trauma to her inner organs and spinal cord, resulting in bladder problems when her vehicle sped out of control and crashed. Since the accident, Exelbert has suffered through numerous surgeries, humiliating social interactions, and the indignity of having little to no control over her bladder.

“The disability of incontinence is more debilitating than my other major injuries,” said Exelbert. “Incontinence leads to a loss of freedom, spontaneity, travelling, activities, and trust in my own body that is heartbreaking.”

With new innovative approaches to OAB treatment, patients like Exelbert may one day find a course of treatment that is right for them. Until that time, more funding and research needs to be dedicated to eradicating this disease.

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For more information on the Society for Women’s Health Research please contact Rachel Griffith at 202-496-5001 or Rachel@swhr.org.

X Conference: All About the Chromosomes

WASHINGTON, D.C. — A packed house of researchers, clinicians, physicians, and non-profit professionals joined the Society for Women’s Health Research (SWHR) for its 2nd annual What a Difference an X Makes: the State of Women’s Health Research scientific conference at the Barbara Jordan Conference Center in Washington, DC on Friday, July 16.

Leading physicians and researchers from across the country congregated in Washington to share new findings and groundbreaking studies in sex-differences research. The conference covered pain and the musculoskeletal system, the brain, the immune system, Hypoactive Sexual Desire Disorder (HSDD), cardiovascular disease and therapeutics, and obesity and comorbidities. These topic areas featured speakers from a wide range of backgrounds and institutions that enriched the dialogue throughout the day.

Highlighting the most recent research on sex and gender differences in knee osteoarthritis, Mary O’Connor, M.D., chair of the Department of Orthopedic Surgery at the Mayo Clinic in Florida, engaged the audience with information on physician bias and whether or not discrimination against women is unconscious or overt. In fact, physicians tend overwhelmingly to recommend men for surgery but not women, even when presented with the same symptoms and conditions. O’Connor shared “that despite identical clinical information, the presentation style of male and female patients may have differed due to the fact women are more narrative, personal and open while men are more business-like, factual and reserved.”

Hypoactive Sexual Desire Disorder, one of the more taboo subjects of the conference but arguably the most dynamic presentation, was given by leading researcher Sheryl Kingsberg, Ph.D., professor of Reproductive Biology at Case Western Reserve University School of Medicine and chief of the Division of Behavioral Medicine at University Hospitals Case Medical Center. “There are many models of the human sexual response, not one being all encompassing,” said Kingsberg. “Because of this, the estimated 43% of all women who experience some sexual dysfunction in their lifetime have a variety of treatment options to follow.”

One of the most important panels of the day was Reducing Cardiovascular Disease in Women – We’ve Come a Long Way Baby but We’re Not There Yet, presented by Virginia Miller, MBA, Ph.D., professor of Surgery and Physiology, College of Medicine at the Mayo Clinic, and President of the Organization for the Study of Sex Differences (OSSD).

Miller included the latest statistics from the American Heart Association on cardiovascular disease mortality trends, noting the number of deaths from heart disease appears to be declining, but the total number of deaths from all cardiovascular diseases in women still exceeds that of men. Heart disease is still the number one killer of women, yet clinical trials do not support this fact. In a 2010 study of affected patient populations and inclusion in randomized clinical trials of cardiovascular disease prevention, women comprised 51% of the patient population for heart failure, but only 29% of the trial; women were also 46% of the coronary artery disease population, but only 25% of the clinical trial and so on.

“We’re not there yet,” said Miller. We need age and sex specific animals in preclinical studies, research into sex differences, integration of basic and clinical scientists, sex specific reporting in clinical trials, and more women in clinical trials.

The X Conference is a major step towards bridging the research gap on biology-based diseases and bringing together the top researchers in the sex-based biology field to share their new data. Sex differences research needs to be a top priority in both private and public research. Because in the end, it’s all about the chromosomes.

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For more information on the Society for Women’s Health Research please contact Rachel Griffith at 202-496-5001 or Rachel@swhr.org.

Tuesday, June 29, 2010

Meeting with CIBR (June 24, 2010)

On June 24, the Society for Women’s Health Research (SWHR) co-sponsored a Capitol Hill event with the Coalition for Imaging & Bioengineering Research (CIBR) and Representative Edolphus Towns (D-NY). The event was of great interest to Hill staff, which began with opening remarks from Representative Towns and former Majority Leader Dick Gephardt.

SWHR, a member of CIBR, brought a unique patient voice to the event, highlighting innovations from approximately 13 different medical technology companies. SWHR explained to Hill staff the key role that diagnostic imaging has in the detection, diagnosis, and treatment of diseases, especially for women.

CIBR was created in 2006, to be a diverse and unified voice in support of imaging research. SHWR supports CIBR and its work to improve imaging research, outcomes, and safety for patients while appropriately utilizing medical imaging.

To see more information, please visit www.CIBR.org.

Monday, June 14, 2010

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Meeting With Secretary Kathleen Sebelius (June 9, 2010)

Phyllis Greenberger, SWHR President and CEO, and Martha Nolan, Vice President, Public Policy met with HHS Secretary Kathleen Sebelius and Dora Hughes, HHS Counselor for Public Health and Science Policy to discuss SWHR’s 20 years of work to improve women’s health: the inclusion of women in clinical trials, sex differences research, and SWHR advocacy efforts. Some of these efforts include comparative effectiveness research (CER) as part of the stimulus bill, Women’s Health Office Act (WHOA) in health care reform, and the appropriate use imaging and diagnostic tools for prevention and early diagnoses.

The Secretary was interested in SWHR’s information regarding women in clinical trials and surprised that sex still is not a fundamental component of all research in the development of drugs, devices and biologics. The Secretary understood how important SWHR’s issues were to determinations being made under comparative effectiveness research, especially with the newly developing Patient-Centered Outcomes Research Institute. The Secretary was informed of SWHR’s testimony, both written and oral, to the NIH/FDA last week regarding the need for consideration of sex differences in “regulatory science,” the newly coined term from the NIH/FDA collaborative.